The wintry weather spelled trouble for drivers early Friday morning, slipping and sliding on the roadways.
One pileup happened on I-75 at the 107 milemarker in Lexington.
Four vehicles, including an ambulance, ran off the road.
A pickup hauling a trailer, another pickup, an SUV and the ambulance were involved.
Police say the drivers hit an ice patch and slid.
A salt truck was called to the scene.
The ambulance was from Chattanooga, Tennessee and on its way back from Ohio, where it dropped off a patient.
No injuries were reported.