The Hal Rogers Parkway is shut down between Manchester and Big Creek due to an accident involving a fuel tanker and another car.
Police tell 27NEWSFIRST they believe the drivers of both vehicles are dead.
The crash happened near mile marker 23. Police say an 18 wheeler and a car crashed causing the truck, that was carrying gasoline, to explode.
Officials say drivers should find an alternate route, because the road will be shut down for several hours.