U.S. 460, also known as Frankfort Road, was closed for most of the day as crews worked to clean up the whiskey.
The driver says he over-corrected on U.S. 460 west of Georgetown this morning.
That caused the whiskey he was hauling to shift and the entire semi overturned.
The driver was not hurt.
Emergency crews say the whiskey does not pose an environmental hazard.
Members from the EPA will be on hand on Thursday to help with the continued cleanup.