The crash happened Wednesday afternoon in Laurel County, between the 41 and 42 mile markers near London.
Police say the semi fell off I-75 and onto a home on Helvetia Road.
The crash left behind quite a big mess, but police say there were no major injuries.
Some people were inside the house at the time of the crash. One person suffered minor injuries and was taken to the hospital.
The semi driver was able to walk away, and was not hurt.
Officials say the semi was carrying 5,500 pounds of chemicals used to clean swimming pools.
Haz-mat crews say none of those chemicals spilled during the crash.
The semi also took out some power lines when it crashed. Crews were working through the afternoon to restore them.