Police remained on the scene for hours early Thursday morning following the discovery of an active meth lab.
It happened at a mobile home on Red Lick Road in Estill County, near the Madison County line.
Kentucky State Police were called there after a passerby noticed a strange smell and notified them.
Troopers arrived and found Kimberly Coomer and Cheree Atkins in the home.
They were arrested.
The homeowner, David Satterfield, was arrested as well, after he returned home.
No one was evacuated.
The home has been deemed unlivable because of the chemical damage and fumes.
Satterfield and Coomer are charged with manufacturing meth. Atkins is charged with complicity to manufacture meth. All three are behind bars in Estill County.