Things are moving again on Interstate 75 in Madison County.
The wreck, involving a semi, happened shortly before 11:00 Tuesday night in the northbound lanes near the 86 milemarker.
It shutdown two of the northbound lanes for about four hours.
Police say the semi flipped when it rear ended a truck.
A car then hit the semi when it tried to slow down.
The semi was carrying filling for mattresses.
One person went to the hospital with minor injuries and was later released.