The fire broke out around five Monday afternoon, at the Taylor Farm on Clintonville Road in Clark County. That's not far from the Fayette County line.
A passerby on nearby Interstate 64 noticed the fire, and alerted authorities.
By the time firefighters arrived on the scene, smoke and flames were shooting into the air.
The barn housed many chickens, most of which the farm's owner says died in the fire.
The fire then spread to a nearby garage, which was also destroyed. A boat inside that garage was pulled away before the flames got to it.
No one was hurt in the fire.
The farm's owner thinks an incubator inside the barn likely caused the fire.
Crews from Clark, Fayette, and Bourbon Counties helped fight the flames.