Discovery Could Lead To More Effective Vaccines

LOUISVILLE, Ky. (AP) - A new generation of more effective vaccines for many diseases may be possible due to a discovery by University of Louisville researchers.

A U-of-L team has explained in the journal "Science," how one vaccine additive generates stronger and longer-lasting immunity than a vaccine alone.

Vaccines rely on a one-two punch in which antigens trigger an immune-system response while additives, called adjuvants (ADD'-ju-vants), strengthen the response. But some adjuvants have toxic side effects, making them unsafe for human use.

The Louisville researchers demonstrated that one adjuvant, called M-P-L-A, boosted immune-system responses in mice without toxic side effects.

(Copyright 2007 by The Associated Press. All Rights Reserved.)

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