The impact smashed a car and caused an SUV to flip on its side.
Police tell us Nicholas Anderson, 19, and Sherry Seward, 49, collided at the crest of a hill on McQueary Road, east of Somerset.
Investigators say the two drivers topped the hill at the same time and didn't see each other coming.
The drivers were the only people in the vehicles.
Seward was flown to UK Hospital. Anderson is recovering at Lake Cumberland Regional Hospital.