It took eleven fire departments all night and most of the morning to put out the flames.
The warehouse fire in Clay County is now being called suspicious.
Officials had to shut down U.S. 421 in downtown Manchester just to fight the fire.
It was a ten hour fight for the Manchester Fire Department
"We were called at 11:30pm Thursday night. When we arrived we had heavy fire on the opposite end of the building here from where we're standing. I immediately called for mutual aid from several other departments,” Jamey Mills said.
Flames were finally put out around 9:30am Friday morning.
Officials say the biggest concern now is making sure the scene is safe and secure before they re-open the road.
The Manchester Police Department along with Kentucky State Police are now trying to figure out how the fire started.
"It's a warehouse building used by a local owner. It does not have electric to it so we believe it's been set somewhere in the second floor of the building,” Manchester Police Chief Chris Fultz said.
The owner of the building believes it was valued between seventy thousand and one hundred thousand dollars.
Highway 421 is now open again.