A Paintsville pain clinic was raided for the second time in a year on Wednesday.
Law enforcement has been investigating the Care More Pain Clinic for years.
A former doctor at the clinic, Richard Albert, was indicted after a raid last year.
Later in the year Albert pleaded guilty to conspiring to illegally prescribe around 50,0000 tablets of the painkiller Percocet.
Wednesday, DEA officials with the help of the Kentucky Attorney General's Office and local law enforcement raided the clinic again on a federal search warrant.
Some patients at the Care More Pain Clinic in Paintsville thought they were going to see the doctor on Wednesday, but they were actually greeted by police.
"The DEA and The Office of the Attorney General of Kentucky asked that we assist them with a search warrant on the premises, and they were looking for records and other evidentiary materials," said Johnson County Sheriff's Deputy Scott Hazlette.
As more people arrived for their appointments, their cars ended up staying in the lot to be impounded while they were taken away in hand cuffs.
Most were arrested for outstanding warrants.
The Paintsville Mayor says this investigation has been going on for several years, and he hopes it's the beginning of the end of the pill problem in the area.
"This is really the culmination of it. We've attempted to find ways to stop people from putting so many pills on the street," said Paintsville Mayor Bob Porter.
DEA officials did not comment on the search, but the mayor says that it's his understanding they will be seeking indictments.
Several boxes were also taken into the clinic to seize records from the business.
The Paintsville Mayor hope the clinic will now be closed for good.